Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling

The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate...

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Autores principales: Chen, Xi-Yao, Jiao, Yang, Zhang, Fu-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524846/
https://www.ncbi.nlm.nih.gov/pubmed/34663467
http://dx.doi.org/10.1186/s40779-021-00347-y
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author Chen, Xi-Yao
Jiao, Yang
Zhang, Fu-Yang
author_facet Chen, Xi-Yao
Jiao, Yang
Zhang, Fu-Yang
author_sort Chen, Xi-Yao
collection PubMed
description The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40779-021-00347-y.
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spelling pubmed-85248462021-10-22 Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling Chen, Xi-Yao Jiao, Yang Zhang, Fu-Yang Mil Med Res Letter to the Editor The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40779-021-00347-y. BioMed Central 2021-10-19 /pmc/articles/PMC8524846/ /pubmed/34663467 http://dx.doi.org/10.1186/s40779-021-00347-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Chen, Xi-Yao
Jiao, Yang
Zhang, Fu-Yang
Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
title Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
title_full Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
title_fullStr Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
title_full_unstemmed Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
title_short Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
title_sort targeting pparα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524846/
https://www.ncbi.nlm.nih.gov/pubmed/34663467
http://dx.doi.org/10.1186/s40779-021-00347-y
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