Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer

BACKGROUND: Liver cancer is one of the most commonly diagnosed cancers and the fourth leading cause of cancer-related death worldwide. Broad-spectrum kinase inhibitors like sorafenib and lenvatinib provide only modest survival benefit to patients with hepatocellular carcinoma (HCC). This study aims...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Yuchen, Wang, Jun, Benedict, Bente, Yang, Chen, van Gemert, Frank, Ma, Xuhui, Gao, Dongmei, Wang, Hui, Zhang, Shu, Lieftink, Cor, Beijersbergen, Roderick L., te Riele, Hein, Qiao, Xiaohang, Gao, Qiang, Sun, Chong, Qin, Wenxin, Bernards, René, Wang, Cun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524847/
https://www.ncbi.nlm.nih.gov/pubmed/34663432
http://dx.doi.org/10.1186/s13073-021-00981-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524847/
https://www.ncbi.nlm.nih.gov/pubmed/34663432
http://dx.doi.org/10.1186/s13073-021-00981-0

Ejemplares similares