Cargando…
Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm
Disease relapse after allogeneic stem cell transplantation is a major cause of treatment-related morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The cellular and molecular mechanisms for MPN relapse are not well understood. Here, we established a murine model of MPN rel...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524893/ https://www.ncbi.nlm.nih.gov/pubmed/34666822 http://dx.doi.org/10.1186/s40164-021-00241-2 |
_version_ | 1784585566810013696 |
---|---|
author | Zhang, Haotian Castiglione, Melissa Zheng, Lei Zhan, Huichun |
author_facet | Zhang, Haotian Castiglione, Melissa Zheng, Lei Zhan, Huichun |
author_sort | Zhang, Haotian |
collection | PubMed |
description | Disease relapse after allogeneic stem cell transplantation is a major cause of treatment-related morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The cellular and molecular mechanisms for MPN relapse are not well understood. Here, we established a murine model of MPN relapse, in which ~ 60% of the MPN recipient mice develop disease relapse after receiving stem cell transplantation with wild-type marrow donor. Using this model, we find that impaired wild-type cell function is associated with MPN disease relapse. We also show that competition between wild-type and JAK2V617F mutant cells can modulate the immune cell composition and PD-L1 expression induced by the JAK2V617F oncogene. These results suggest that cell competition between wild-type donor cells and JAK2V617F mutant recipient cells can prevent MPN disease relapse after stem cell transplantation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40164-021-00241-2. |
format | Online Article Text |
id | pubmed-8524893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85248932021-10-22 Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm Zhang, Haotian Castiglione, Melissa Zheng, Lei Zhan, Huichun Exp Hematol Oncol Letter to the Editor Disease relapse after allogeneic stem cell transplantation is a major cause of treatment-related morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The cellular and molecular mechanisms for MPN relapse are not well understood. Here, we established a murine model of MPN relapse, in which ~ 60% of the MPN recipient mice develop disease relapse after receiving stem cell transplantation with wild-type marrow donor. Using this model, we find that impaired wild-type cell function is associated with MPN disease relapse. We also show that competition between wild-type and JAK2V617F mutant cells can modulate the immune cell composition and PD-L1 expression induced by the JAK2V617F oncogene. These results suggest that cell competition between wild-type donor cells and JAK2V617F mutant recipient cells can prevent MPN disease relapse after stem cell transplantation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40164-021-00241-2. BioMed Central 2021-10-19 /pmc/articles/PMC8524893/ /pubmed/34666822 http://dx.doi.org/10.1186/s40164-021-00241-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Letter to the Editor Zhang, Haotian Castiglione, Melissa Zheng, Lei Zhan, Huichun Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
title | Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
title_full | Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
title_fullStr | Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
title_full_unstemmed | Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
title_short | Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
title_sort | cell competition between wild-type and jak2v617f mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524893/ https://www.ncbi.nlm.nih.gov/pubmed/34666822 http://dx.doi.org/10.1186/s40164-021-00241-2 |
work_keys_str_mv | AT zhanghaotian cellcompetitionbetweenwildtypeandjak2v617fmutantcellspreventsdiseaserelapseafterstemcelltransplantationinamurinemodelofmyeloproliferativeneoplasm AT castiglionemelissa cellcompetitionbetweenwildtypeandjak2v617fmutantcellspreventsdiseaserelapseafterstemcelltransplantationinamurinemodelofmyeloproliferativeneoplasm AT zhenglei cellcompetitionbetweenwildtypeandjak2v617fmutantcellspreventsdiseaserelapseafterstemcelltransplantationinamurinemodelofmyeloproliferativeneoplasm AT zhanhuichun cellcompetitionbetweenwildtypeandjak2v617fmutantcellspreventsdiseaserelapseafterstemcelltransplantationinamurinemodelofmyeloproliferativeneoplasm |