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Protein kinase C regulates organic anion transporter 1 through phosphorylating ubiquitin ligase Nedd4–2

BACKGROUND: Organic anion transporter 1 (OAT1) is a drug transporter expressed on the basolateral membrane of the proximal tubule cells in kidneys. It plays an essential role in the disposition of numerous clinical therapeutics, impacting their pharmacological and toxicological properties. The activ...

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Detalles Bibliográficos
Autores principales: Yu, Zhou, Liu, Chenchang, Zhang, Jinghui, Liang, Zhengxuan, You, Guofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524912/
https://www.ncbi.nlm.nih.gov/pubmed/34663225
http://dx.doi.org/10.1186/s12860-021-00393-3