The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccination

Development of effective HIV-1 vaccines requires synergy between innate and adaptive immune cells. We show that induction of the transcription factor CREB1 and its target genes by the recombinant canarypox vector ALVAC+Alum augments immunogenicity in Non-human primates (NHPs) and predicts reduced HI...

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Detalles Bibliográficos
Autores principales: Tomalka, Jeffrey Alan, Pelletier, Adam Nicolas, Fourati, Slim, Latif, Muhammad Bilal, Sharma, Ashish, Furr, Kathryn, Carlson, Kevin, Lifton, Michelle, Gonzalez, Ana, Wilkinson, Peter, Franchini, Genoveffa, Parks, Robert, Letvin, Norman, Yates, Nicole, Seaton, Kelly, Tomaras, Georgia, Tartaglia, Jim, Robb, Merlin, Michael, Nelson, Koup, Richard, Haynes, Barton, Santra, Sampa, Sekaly, Rafick Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525330/
https://www.ncbi.nlm.nih.gov/pubmed/34556879
http://dx.doi.org/10.1038/s41590-021-01026-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525330/
https://www.ncbi.nlm.nih.gov/pubmed/34556879
http://dx.doi.org/10.1038/s41590-021-01026-9

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