Propensity of IgA to self-aggregate via tailpiece cysteine-471 and treatment of IgA nephropathy using cysteamine

IgA nephropathy is caused by deposition of circulatory IgA1 in the kidney. Hypogalactosylated IgA1 has the propensity to form poly-IgA aggregates that are prone to deposition. Herein, we purified poly-IgA from the plasma of patients with IgA nephropathy and showed that the complex is susceptible to...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Xinfang, Gao, Li, Liu, Pan, Lv, Jicheng, Lu, Wan-Hong, Zhang, Hong, Jin, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525636/
https://www.ncbi.nlm.nih.gov/pubmed/34428184
http://dx.doi.org/10.1172/jci.insight.150551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525636/
https://www.ncbi.nlm.nih.gov/pubmed/34428184
http://dx.doi.org/10.1172/jci.insight.150551

Ejemplares similares