The Intraocular Pressure Lowering Effect of a Dual Kinase Inhibitor (ITRI-E-(S)4046) in Ocular Hypertensive Animal Models

PURPOSE: The purpose of this study was to develop a preclinical compound, ITRI-E-(S)4046, a dual synergistic inhibitor of myosin light chain kinase 4 (MYLK4) and Rho-related protein kinase (ROCK), for reducing intraocular pressure (IOP). METHODS: ITRI-E-(S)4046 is an amino-pyrazole derivative with p...

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Detalles Bibliográficos
Autores principales: Chen, Yi-Hsun, Lin, Wan-Ying, Huang, Yu Chuan, Ho, Wan Yu, Fu, Chih-Wei, Tu, Chia-Mu, Hwang, Chrong-Shiong, Hung, Chiu-Lien, Lin, Ming-Chun, Cheng, Felice, Wang, Yen-Jen, Chen, Chih-Hung, Chou, Shuen-Hsiang, She, Meng-Ping, Yang, Chia-Yi, Cheng, Hui-Ling, Liu, Chih-Peng, Lu, Da-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
New Developments in Vision Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525843/
https://www.ncbi.nlm.nih.gov/pubmed/34661609
http://dx.doi.org/10.1167/iovs.62.13.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525843/
https://www.ncbi.nlm.nih.gov/pubmed/34661609
http://dx.doi.org/10.1167/iovs.62.13.12

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