Small-molecule Akt-activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2

BACKGROUND: The non-cancerous functions of Akt in the airway are understudied. In some tissues, Akt phosphorylates and activates endothelial nitric oxide synthase (eNOS) to produce nitric oxide (NO) that has anti-inflammatory effects. NO production has antibacterial and antiviral effects in the airw...

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Detalles Bibliográficos
Autores principales: Gopallawa, Indiwari, Kuek, Li Eon, Adappa, Nithin D., Palmer, James N., Lee, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525858/
https://www.ncbi.nlm.nih.gov/pubmed/34666758
http://dx.doi.org/10.1186/s12931-021-01865-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525858/
https://www.ncbi.nlm.nih.gov/pubmed/34666758
http://dx.doi.org/10.1186/s12931-021-01865-y

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