CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas

Therapeutic efficacies of orally administrated hydrophobic chemodrugs are decreased by poor water solubilities and reduced oral bioavailabilities by P-glycoprotein (P-gp) and CYP450. In this study, CPT11 alone or combined with dual-function inhibitors (baicalein (BA) silymarin (SM), glycyrrhizic aci...

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Detalles Bibliográficos
Autores principales: Chen, Ling-Chun, Cheng, Wei-Jie, Lin, Shyr-Yi, Hung, Ming-Tse, Sheu, Ming-Thau, Lin, Hong-Liang, Hsieh, Chien-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525948/
https://www.ncbi.nlm.nih.gov/pubmed/34662257
http://dx.doi.org/10.1080/10717544.2021.1989087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525948/
https://www.ncbi.nlm.nih.gov/pubmed/34662257
http://dx.doi.org/10.1080/10717544.2021.1989087

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