Cargando…

CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas

Therapeutic efficacies of orally administrated hydrophobic chemodrugs are decreased by poor water solubilities and reduced oral bioavailabilities by P-glycoprotein (P-gp) and CYP450. In this study, CPT11 alone or combined with dual-function inhibitors (baicalein (BA) silymarin (SM), glycyrrhizic aci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Ling-Chun, Cheng, Wei-Jie, Lin, Shyr-Yi, Hung, Ming-Tse, Sheu, Ming-Thau, Lin, Hong-Liang, Hsieh, Chien-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525948/ https://www.ncbi.nlm.nih.gov/pubmed/34662257 http://dx.doi.org/10.1080/10717544.2021.1989087

Ejemplares similares

Preparation and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) for Enhanced Oral Bioavailability of Nilotinib
por: Lin, Hong-Liang, et al.
Publicado: (2020)

Complex Hydrogels Composed of Chitosan with Ring-opened Polyvinyl Pyrrolidone as a Gastroretentive Drug Dosage Form to Enhance the Bioavailability of Bisphosphonates
por: Su, Chia-Yu, et al.
Publicado: (2018)

Synergistic Combination of Irinotecan and Rapamycin Orally Delivered by Nanoemulsion for Enhancing Therapeutic Efficacy of Pancreatic Cancer
por: Liu, Yu-Hsuan, et al.
Publicado: (2023)

Development of a Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) of Ciprofloxacin Hydrochloride
por: Liang, Yu-Kai, et al.
Publicado: (2023)

Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate
por: Chen, Ying-Chen, et al.
Publicado: (2013)

Swelling/Floating Capability and Drug Release Characterizations of Gastroretentive Drug Delivery System Based on a Combination of Hydroxyethyl Cellulose and Sodium Carboxymethyl Cellulose
por: Chen, Ying-Chen, et al.
Publicado: (2015)

Self-Nanoemulsifying Drug Delivery Systems for Enhancing Solubility, Permeability, and Bioavailability of Sesamin
por: Wang, Chih-Yuan, et al.
Publicado: (2020)

Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect
por: Kim, Dongyeop, et al.
Publicado: (2013)

Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer
por: Cheng, Wei-Jie, et al.
Publicado: (2022)

Nanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide
por: Yen, Ching-Chi, et al.
Publicado: (2018)

Carfilzomib and Paclitaxel Co-Loaded Protein Nanoparticles an Effective Therapy Against Pancreatic Adenocarcinomas
por: Cheng, Wen-Ting, et al.
Publicado: (2021)

Self-Nanoemulsifying Drug Delivery System for Resveratrol: Enhanced Oral Bioavailability and Reduced Physical Fatigue in Rats
por: Yen, Ching-Chi, et al.
Publicado: (2017)

Self-Nanoemulsifying Drug Delivery System for Enhanced Bioavailability of Madecassic Acid: In vitro and in vivo Evaluation
por: Lin, Li, et al.
Publicado: (2023)

Self-Nanoemulsifying Drug Delivery System of Lutein: Physicochemical Properties and Effect on Bioavailability of Warfarin
por: Yoo, Juno, et al.
Publicado: (2013)

Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D
por: Ke, Zhongcheng, et al.
Publicado: (2016)

Active Tumoral/Tumor Environmental Dual-Targeting by Non-Covalently Arming with Trispecific Antibodies or Dual-Bispecific Antibodies on Docetaxel-Loaded mPEGylated Nanocarriers to Enhance Chemotherapeutic Efficacy and Minimize Systemic Toxicity
por: Cheng, Wei-Jie, et al.
Publicado: (2021)

Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability
por: Lin, Hong-Liang, et al.
Publicado: (2021)

Excipient Nanoemulsions for Improving Oral Bioavailability of Bioactives
por: Salvia-Trujillo, Laura, et al.
Publicado: (2016)

Antioxidant, Antibacterial and Antibiofilm Activity of Nanoemulsion-Based Natural Compound Delivery Systems Compared with Non-Nanoemulsified Versions
por: da Silva, Bruno Dutra, et al.
Publicado: (2023)

In situ formation of nanocrystals from a self-microemulsifying drug delivery system to enhance oral bioavailability of fenofibrate
por: Lin, You-Meei, et al.
Publicado: (2011)

Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl
por: El Nabarawi, Mohamed A, et al.
Publicado: (2017)

Enhancement of Oral Bioavailability of Ibandronate Through Gastroretentive Raft Forming Drug Delivery System: In Vitro and In Vivo Evaluation
por: Hanif, Muhammad, et al.
Publicado: (2020)

Self-Nanoemulsifying Drug Delivery System of Tetrandrine for Improved Bioavailability: Physicochemical Characterization and Pharmacokinetic Study
por: Liu, Chunxia, et al.
Publicado: (2018)

Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS)
por: Ashfaq, Mehran, et al.
Publicado: (2022)

Tadalafil-Loaded Self-Nanoemulsifying Chewable Tablets for Improved Bioavailability: Design, In Vitro, and In Vivo Testing
por: Ali, Hany S. M., et al.
Publicado: (2022)

Formulation and characterization of Cefuroxime Axetil nanoemulsion for improved bioavailability
por: Patel, Yomesh, et al.
Publicado: (2012)

Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs
por: Preeti, et al.
Publicado: (2023)

Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral Drug Bioavailability and Patient Compliance Implications
por: Vrettos, Napoleon-Nikolaos, et al.
Publicado: (2021)

Design and Development of Novel Dual-Compartment Capsule for Improved Gastroretention
por: Patil, Ganesh B., et al.
Publicado: (2013)

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation
por: Baloch, Jeand, et al.
Publicado: (2019)

Custom fractional factorial designs to develop atorvastatin self-nanoemulsifying and nanosuspension delivery systems – enhancement of oral bioavailability
por: Hashem, Fahima M, et al.
Publicado: (2015)

Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and bioavailability of ezetimibe
por: Rashid, Rehmana, et al.
Publicado: (2015)

Development of an Orally Bioavailable Isoliquiritigenin Self-Nanoemulsifying Drug Delivery System to Effectively Treat Ovalbumin-Induced Asthma
por: Cao, Mingzhuo, et al.
Publicado: (2020)

Nanoemulsion and Nanoliposome Based Strategies for Improving Anthocyanin Stability and Bioavailability
por: Chen, Bing-Huei, et al.
Publicado: (2019)

Development and characterisation of ibuprofen-loaded nanoemulsion with enhanced oral bioavailability
por: Anuar, Nurfazreen, et al.
Publicado: (2020)

Absorption and Bioavailability of Novel UltraShear Nanoemulsion of Cannabidiol in Rats
por: ElSohly, Mahmoud A., et al.
Publicado: (2023)

Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self‐nanoemulsions
por: Wang, Yiling, et al.
Publicado: (2020)

Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery
por: Chen, Ling-Chun, et al.
Publicado: (2023)

A simple and sensitive high-performance liquid chromatography method for determination of ciprofloxacin in bioavailability studies of conventional and gastroretentive prolonged-release formulations
por: Emami, Jaber, et al.
Publicado: (2016)

Gastroretentive microballoons of metformin: Formulation development and characterization
por: Yadav, Akash, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_imv6ef4po28d1rnkfbrsslv9id