Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila

We investigated in larval and adult Drosophila models whether loss of the mitochondrial chaperone Hsc70-5 is sufficient to cause pathological alterations commonly observed in Parkinson disease. At affected larval neuromuscular junctions, no effects on terminal size, bouton size or number, synapse si...

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Detalles Bibliográficos
Autores principales: Zhu, Jun-yi, Hannan, Shabab B., Dräger, Nina M., Vereshchagina, Natalia, Krahl, Ann-Christin, Fu, Yulong, Elliott, Christopher J.H., Han, Zhe, Jahn, Thomas R., Rasse, Tobias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526020/
https://www.ncbi.nlm.nih.gov/pubmed/33404278
http://dx.doi.org/10.1080/15548627.2020.1871211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526020/
https://www.ncbi.nlm.nih.gov/pubmed/33404278
http://dx.doi.org/10.1080/15548627.2020.1871211

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