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Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila

We investigated in larval and adult Drosophila models whether loss of the mitochondrial chaperone Hsc70-5 is sufficient to cause pathological alterations commonly observed in Parkinson disease. At affected larval neuromuscular junctions, no effects on terminal size, bouton size or number, synapse si...

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Detalles Bibliográficos
Autores principales:	Zhu, Jun-yi, Hannan, Shabab B., Dräger, Nina M., Vereshchagina, Natalia, Krahl, Ann-Christin, Fu, Yulong, Elliott, Christopher J.H., Han, Zhe, Jahn, Thomas R., Rasse, Tobias M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526020/ https://www.ncbi.nlm.nih.gov/pubmed/33404278 http://dx.doi.org/10.1080/15548627.2020.1871211

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