Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2(R1441G) mice

Mitochondrial dysfunction causes energy deficiency and nigrostriatal neurodegeneration which is integral to the pathogenesis of Parkinson disease (PD). Clearance of defective mitochondria involves fission and ubiquitin-dependent degradation via mitophagy to maintain energy homeostasis. We hypothesiz...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Huifang, Ho, Philip Wing-Lok, Leung, Chi-Ting, Pang, Shirley Yin-Yu, Chang, Eunice Eun Seo, Choi, Zoe Yuen-Kiu, Kung, Michelle Hiu-Wai, Ramsden, David Boyer, Ho, Shu-Leong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper- Translational
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526027/
https://www.ncbi.nlm.nih.gov/pubmed/33300446
http://dx.doi.org/10.1080/15548627.2020.1850008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526027/
https://www.ncbi.nlm.nih.gov/pubmed/33300446
http://dx.doi.org/10.1080/15548627.2020.1850008

Ejemplares similares