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Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants

Advances in genome sequencing have improved our understanding of the genetic basis of human diseases, and thousands of human genes have been associated with different diseases. Recent genomic adaptation at disease genes has not been well characterized. Here, we compare the rate of strong recent adap...

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Detalles Bibliográficos
Autores principales: Di, Chenlu, Murga Moreno, Jesus, Salazar-Tortosa, Diego F, Lauterbur, M Elise, Enard, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526059/
https://www.ncbi.nlm.nih.gov/pubmed/34636724
http://dx.doi.org/10.7554/eLife.69026