CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation

CD47 protects healthy cells from macrophage attack by binding to signal regulatory protein α (SIRPα), while its upregulation in cancer prevents immune clearance. Systemic treatment with CD47 antibodies requires a weakened Fc-mediated effector function or lower CD47-binding affinity to prevent side e...

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Detalles Bibliográficos
Autores principales: Billerhart, Magdalena, Schönhofer, Monika, Schueffl, Hemma, Polzer, Wolfram, Pichler, Julia, Decker, Simon, Taschauer, Alexander, Maier, Julia, Anton, Martina, Eckmann, Sebastian, Blaschek, Manuel, Heffeter, Petra, Sami, Haider, Ogris, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526499/
https://www.ncbi.nlm.nih.gov/pubmed/34729396
http://dx.doi.org/10.1016/j.omto.2021.09.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526499/
https://www.ncbi.nlm.nih.gov/pubmed/34729396
http://dx.doi.org/10.1016/j.omto.2021.09.005

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