Regulation of local GTP availability controls RAC1 activity and cell invasion

Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than the in vitro RAC1 GTP dissociation constant (RAC1-GT...

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Detalles Bibliográficos
Autores principales: Bianchi-Smiraglia, Anna, Wolff, David W., Marston, Daniel J., Deng, Zhiyong, Han, Zhannan, Moparthy, Sudha, Wombacher, Rebecca M., Mussell, Ashley L., Shen, Shichen, Chen, Jialin, Yun, Dong-Hyun, O’Brien Cox, Anderson, Furdui, Cristina M., Hurley, Edward, Feltri, Maria Laura, Qu, Jun, Hollis, Thomas, Kengne, Jules Berlin Nde, Fongang, Bernard, Sousa, Rui J., Kandel, Mikhail E., Kandel, Eugene S., Hahn, Klaus M., Nikiforov, Mikhail A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526568/
https://www.ncbi.nlm.nih.gov/pubmed/34667203
http://dx.doi.org/10.1038/s41467-021-26324-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526568/
https://www.ncbi.nlm.nih.gov/pubmed/34667203
http://dx.doi.org/10.1038/s41467-021-26324-6

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