Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) has been shown to activate the eIF2α kinase PERK to directly regulate translation initiation. Tight control of PERK-eIF2α signaling has been shown to be necessary for normal long-lasting synaptic plasticity and cognitive funct...

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Detalles Bibliográficos
Autores principales: Longo, Francesco, Mancini, Maria, Ibraheem, Pierre L., Aryal, Sameer, Mesini, Caterina, Patel, Jyoti C., Penhos, Elena, Rahman, Nazia, Mamcarz, Maggie, Santini, Emanuela, Rice, Margaret E., Klann, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526653/
https://www.ncbi.nlm.nih.gov/pubmed/33879865
http://dx.doi.org/10.1038/s41380-021-01099-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526653/
https://www.ncbi.nlm.nih.gov/pubmed/33879865
http://dx.doi.org/10.1038/s41380-021-01099-w

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