Altered protein O-GlcNAcylation in placentas from mothers with diabetes causes aberrant endocytosis in placental trophoblast cells

Women with pre-existing diabetes have an increased risk of poor pregnancy outcomes, including disordered fetal growth, caused by changes to placental function. Here we investigate the possibility that the hexosamine biosynthetic pathway, which utilises cellular nutrients to regulate protein function...

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Detalles Bibliográficos
Autores principales: Palin, Victoria, Russell, Matthew, Graham, Robert, Aplin, John D., Westwood, Melissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526670/
https://www.ncbi.nlm.nih.gov/pubmed/34667181
http://dx.doi.org/10.1038/s41598-021-00045-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526670/
https://www.ncbi.nlm.nih.gov/pubmed/34667181
http://dx.doi.org/10.1038/s41598-021-00045-8

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