Intracellular Lipid Accumulation and Mitochondrial Dysfunction Accompanies Endoplasmic Reticulum Stress Caused by Loss of the Co-chaperone DNAJC3

Recessive mutations in DNAJC3, an endoplasmic reticulum (ER)-resident BiP co-chaperone, have been identified in patients with multisystemic neurodegeneration and diabetes mellitus. To further unravel these pathomechanisms, we employed a non-biased proteomic approach and identified dysregulation of s...

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Detalles Bibliográficos
Autores principales: Jennings, Matthew J., Hathazi, Denisa, Nguyen, Chi D. L., Munro, Benjamin, Münchberg, Ute, Ahrends, Robert, Schenck, Annette, Eidhof, Ilse, Freier, Erik, Synofzik, Matthis, Horvath, Rita, Roos, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526738/
https://www.ncbi.nlm.nih.gov/pubmed/34692675
http://dx.doi.org/10.3389/fcell.2021.710247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526738/
https://www.ncbi.nlm.nih.gov/pubmed/34692675
http://dx.doi.org/10.3389/fcell.2021.710247

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