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A hierarchy of coupling free energies underlie the thermodynamic and functional architecture of protein structures

Protein sequences and structures evolve by satisfying varied physical and biochemical constraints. This multi-level selection is enabled not just by the patterning of amino acids on the sequence, but also via coupling between residues in the native structure. Here, we employ an energetically detaile...

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Detalles Bibliográficos
Autores principales: Naganathan, Athi N., Kannan, Adithi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526763/
https://www.ncbi.nlm.nih.gov/pubmed/34704074
http://dx.doi.org/10.1016/j.crstbi.2021.09.003