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A hierarchy of coupling free energies underlie the thermodynamic and functional architecture of protein structures
Protein sequences and structures evolve by satisfying varied physical and biochemical constraints. This multi-level selection is enabled not just by the patterning of amino acids on the sequence, but also via coupling between residues in the native structure. Here, we employ an energetically detaile...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526763/ https://www.ncbi.nlm.nih.gov/pubmed/34704074 http://dx.doi.org/10.1016/j.crstbi.2021.09.003 |