SetD7 (Set7/9) is a novel target of PPARγ that promotes the adaptive pancreatic β-cell glycemic response

Loss of functional pancreatic β-cell mass leads to type 2 diabetes (T2D), attributable to modified β-cell-dependent adaptive gene expression patterns. SetD7 is a histone methyltransferase enriched in pancreatic islets that mono- and dimethylates histone-3-lysine-4 (H3K4), promoting euchromatin modif...

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Detalles Bibliográficos
Autores principales: Jetton, Thomas L., Flores-Bringas, Patricio, Leahy, John L., Gupta, Dhananjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526774/
https://www.ncbi.nlm.nih.gov/pubmed/34592314
http://dx.doi.org/10.1016/j.jbc.2021.101250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526774/
https://www.ncbi.nlm.nih.gov/pubmed/34592314
http://dx.doi.org/10.1016/j.jbc.2021.101250

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