Novel TCR-like CAR-T cells targeting an HLA∗0201-restricted SSX2 epitope display strong activity against acute myeloid leukemia

The synovial sarcoma X breakpoint 2 (SSX2) belongs to a multigene family of cancer-testis antigens and can be found overexpressed in multiple malignancies. Its restricted expression in immune-privileged normal tissues suggest that SSX2 may be a relevant target antigen for chimeric antigen receptor (...

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Detalles Bibliográficos
Autores principales: Raskin, Scott, Van Pelt, Stacey, Toner, Keri, Balakrishnan, Preethi Bala, Dave, Hema, Bollard, Catherine M., Yvon, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526777/
https://www.ncbi.nlm.nih.gov/pubmed/34729377
http://dx.doi.org/10.1016/j.omtm.2021.09.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526777/
https://www.ncbi.nlm.nih.gov/pubmed/34729377
http://dx.doi.org/10.1016/j.omtm.2021.09.008

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