Brain-Derived Neurotrophic Factor Secreting Human Mesenchymal Stem Cells Improve Outcomes in Rett Syndrome Mouse Models

Rett syndrome (RTT) is a severe X-linked dominant neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene; MeCP2 regulates the expression of brain-derived neurotrophic factor (BDNF) and increasing BDNF levels ameliorates RTT symptoms. However, the clinical ap...

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Detalles Bibliográficos
Autores principales: Kim, Hyo Jeong, Bayarsaikhan, Delger, Lee, Jaesuk, Bayarsaikhan, Govigerel, Lee, Bonghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526791/
https://www.ncbi.nlm.nih.gov/pubmed/34690674
http://dx.doi.org/10.3389/fnins.2021.725398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526791/
https://www.ncbi.nlm.nih.gov/pubmed/34690674
http://dx.doi.org/10.3389/fnins.2021.725398

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