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Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions
Protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells, thereby templating their own aberrant conformation onto soluble homotypic proteins. Proteopathic seeds can be released into the extracellular space, secreted in association with extracellu...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526834/ https://www.ncbi.nlm.nih.gov/pubmed/34667166 http://dx.doi.org/10.1038/s41467-021-25855-2 |