Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells, thereby templating their own aberrant conformation onto soluble homotypic proteins. Proteopathic seeds can be released into the extracellular space, secreted in association with extracellu...

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Detalles Bibliográficos
Autores principales: Liu, Shu, Hossinger, André, Heumüller, Stefanie-Elisabeth, Hornberger, Annika, Buravlova, Oleksandra, Konstantoulea, Katerina, Müller, Stephan A., Paulsen, Lydia, Rousseau, Frederic, Schymkowitz, Joost, Lichtenthaler, Stefan F., Neumann, Manuela, Denner, Philip, Vorberg, Ina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526834/
https://www.ncbi.nlm.nih.gov/pubmed/34667166
http://dx.doi.org/10.1038/s41467-021-25855-2

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