SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas

Patients with germline neurofibromatosis type 1 (NF1) microdeletions frequently exhibit hereditary syndromes such as cardiovascular anomalies and have an increased risk of malignant peripheral nerve sheath tumors (MPNSTs). This study aimed to identify the genes codeleted with SUZ12 that are related...

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Detalles Bibliográficos
Autores principales: Li, Weijie, Hu, Chenhao, Zhang, Xingnan, Wang, Binbin, Li, Zhen, Ling, Miao, Sun, Shengqiao, Guo, Chao, Li, Dezhi, Liu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526866/
https://www.ncbi.nlm.nih.gov/pubmed/34692515
http://dx.doi.org/10.3389/fonc.2021.738300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526866/
https://www.ncbi.nlm.nih.gov/pubmed/34692515
http://dx.doi.org/10.3389/fonc.2021.738300

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