Lactate Alters Metabolism in Human Macrophages and Improves Their Ability to Kill Mycobacterium tuberculosis

In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lactate, the end-product of glycolysis, accumulates in...

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Detalles Bibliográficos
Autores principales: Ó Maoldomhnaigh, Cilian, Cox, Donal J., Phelan, James J., Mitermite, Morgane, Murphy, Dearbhla M., Leisching, Gina, Thong, Lorraine, O’Leary, Seónadh M., Gogan, Karl M., McQuaid, Kate, Coleman, Amy M., Gordon, Stephen V., Basdeo, Sharee A., Keane, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526932/
https://www.ncbi.nlm.nih.gov/pubmed/34691015
http://dx.doi.org/10.3389/fimmu.2021.663695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526932/
https://www.ncbi.nlm.nih.gov/pubmed/34691015
http://dx.doi.org/10.3389/fimmu.2021.663695

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