Methyltransferase-Deficient Avian Flaviviruses Are Attenuated Due to Suppression of Viral RNA Translation and Induction of a Higher Innate Immunity

The 5’ end of the flavivirus genome contains a type 1 cap structure formed by sequential N-7 and 2’-O methylations by viral methyltransferase (MTase). Cap methylation of flavivirus genome is an essential structural modification to ensure the normal proliferation of the virus. Tembusu virus (TMUV) (g...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xuedong, Zhang, Yuetian, Wang, Mingshu, Chen, Shun, Liu, Mafeng, Zhu, Dekang, Zhao, Xinxin, Wu, Ying, Yang, Qiao, Zhang, Shaqiu, Huang, Juan, Ou, Xumin, Zhang, Ling, Liu, Yunya, Yu, Yanling, Gao, Qun, Mao, Sai, Sun, Di, Tian, Bin, Yin, Zhongqiong, Jing, Bo, Cheng, Anchun, Jia, Renyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526935/
https://www.ncbi.nlm.nih.gov/pubmed/34691066
http://dx.doi.org/10.3389/fimmu.2021.751688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526935/
https://www.ncbi.nlm.nih.gov/pubmed/34691066
http://dx.doi.org/10.3389/fimmu.2021.751688

Ejemplares similares