Methyltransferase-Deficient Avian Flaviviruses Are Attenuated Due to Suppression of Viral RNA Translation and Induction of a Higher Innate Immunity

The 5’ end of the flavivirus genome contains a type 1 cap structure formed by sequential N-7 and 2’-O methylations by viral methyltransferase (MTase). Cap methylation of flavivirus genome is an essential structural modification to ensure the normal proliferation of the virus. Tembusu virus (TMUV) (g...

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Detalles Bibliográficos
Autores principales: Wu, Xuedong, Zhang, Yuetian, Wang, Mingshu, Chen, Shun, Liu, Mafeng, Zhu, Dekang, Zhao, Xinxin, Wu, Ying, Yang, Qiao, Zhang, Shaqiu, Huang, Juan, Ou, Xumin, Zhang, Ling, Liu, Yunya, Yu, Yanling, Gao, Qun, Mao, Sai, Sun, Di, Tian, Bin, Yin, Zhongqiong, Jing, Bo, Cheng, Anchun, Jia, Renyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526935/
https://www.ncbi.nlm.nih.gov/pubmed/34691066
http://dx.doi.org/10.3389/fimmu.2021.751688

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