Synthesis of Sitagliptin Intermediate by a Multi-Enzymatic Cascade System Using Lipase and Transaminase With Benzylamine as an Amino Donor

Herein, we report the development of a multi-enzyme cascade using transaminase (TA), esterase, aldehyde reductase (AHR), and formate dehydrogenase (FDH), using benzylamine as an amino donor to synthesize the industrially important compound sitagliptin intermediate. A panel of 16 TAs was screened usi...

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Detalles Bibliográficos
Autores principales: Khobragade, Taresh P., Sarak, Sharad, Pagar, Amol D., Jeon, Hyunwoo, Giri, Pritam, Yun, Hyungdon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526967/
https://www.ncbi.nlm.nih.gov/pubmed/34692666
http://dx.doi.org/10.3389/fbioe.2021.757062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526967/
https://www.ncbi.nlm.nih.gov/pubmed/34692666
http://dx.doi.org/10.3389/fbioe.2021.757062

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