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Synthesis of Sitagliptin Intermediate by a Multi-Enzymatic Cascade System Using Lipase and Transaminase With Benzylamine as an Amino Donor

Herein, we report the development of a multi-enzyme cascade using transaminase (TA), esterase, aldehyde reductase (AHR), and formate dehydrogenase (FDH), using benzylamine as an amino donor to synthesize the industrially important compound sitagliptin intermediate. A panel of 16 TAs was screened usi...

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Detalles Bibliográficos
Autores principales:	Khobragade, Taresh P., Sarak, Sharad, Pagar, Amol D., Jeon, Hyunwoo, Giri, Pritam, Yun, Hyungdon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526967/ https://www.ncbi.nlm.nih.gov/pubmed/34692666 http://dx.doi.org/10.3389/fbioe.2021.757062

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