Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition

Plasmodium parasites cause malaria and are responsible annually for hundreds of thousands of deaths. Kinesins are a superfamily of microtubule-dependent ATPases that play important roles in the parasite replicative machinery, which is a potential target for antiparasite drugs. Kinesin-5, a molecular...

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Detalles Bibliográficos
Autores principales: Cook, Alexander D., Roberts, Anthony J., Atherton, Joseph, Tewari, Rita, Topf, Maya, Moores, Carolyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526983/
https://www.ncbi.nlm.nih.gov/pubmed/34375637
http://dx.doi.org/10.1016/j.jbc.2021.101063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526983/
https://www.ncbi.nlm.nih.gov/pubmed/34375637
http://dx.doi.org/10.1016/j.jbc.2021.101063

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