Cargando…

Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition

Plasmodium parasites cause malaria and are responsible annually for hundreds of thousands of deaths. Kinesins are a superfamily of microtubule-dependent ATPases that play important roles in the parasite replicative machinery, which is a potential target for antiparasite drugs. Kinesin-5, a molecular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cook, Alexander D., Roberts, Anthony J., Atherton, Joseph, Tewari, Rita, Topf, Maya, Moores, Carolyn A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526983/ https://www.ncbi.nlm.nih.gov/pubmed/34375637 http://dx.doi.org/10.1016/j.jbc.2021.101063

Ejemplares similares

Cryo-EM structure of the Ustilago maydis kinesin-5 motor domain bound to microtubules
por: von Loeffelholz, Ottilie, et al.
Publicado: (2019)

Cryo-EM of kinesin-binding protein: challenges and opportunities from protein-surface interactions
por: Atherton, Joseph, et al.
Publicado: (2021)

A microtubule RELION-based pipeline for cryo-EM image processing
por: Cook, Alexander D., et al.
Publicado: (2020)

Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission
por: Liu, Tianyang, et al.
Publicado: (2022)

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
por: Atherton, Joseph, et al.
Publicado: (2014)

Microtubule structure by cryo-EM: snapshots of dynamic instability
por: Manka, Szymon W., et al.
Publicado: (2018)

Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy
por: Peña, Alejandro, et al.
Publicado: (2020)

Author Correction: Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission
por: Liu, Tianyang, et al.
Publicado: (2023)

Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy
por: Peña, Alejandro, et al.
Publicado: (2021)

Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s
por: Benoit, Matthieu P.M.H., et al.
Publicado: (2018)

Cryo-EM Structure (4.5-Å) of Yeast Kinesin-5–Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance
por: von Loeffelholz, Ottilie, et al.
Publicado: (2019)

Cryo-EM structure of VASH1-SVBP bound to microtubules
por: Li, Faxiang, et al.
Publicado: (2020)

Microtubule architecture in vitro and in cells revealed by cryo-electron tomography
por: Atherton, Joseph, et al.
Publicado: (2018)

Author Correction: Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s
por: Benoit, Matthieu P. M. H., et al.
Publicado: (2018)

Cryo‐EM targets in CASP14
por: Cragnolini, Tristan, et al.
Publicado: (2021)

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry
por: Atherton, Joseph, et al.
Publicado: (2017)

Mapping the Processivity Determinants of the Kinesin-3 Motor Domain
por: Scarabelli, Guido, et al.
Publicado: (2015)

Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins
por: Wang, Xiangli, et al.
Publicado: (2021)

Regulation of KinI kinesin ATPase activity by binding to the microtubule lattice
por: Moores, Carolyn A., et al.
Publicado: (2003)

Assessment of protein–protein interfaces in cryo-EM derived assemblies
por: Malhotra, Sony, et al.
Publicado: (2021)

Structural basis of human kinesin-8 function and inhibition
por: Locke, Julia, et al.
Publicado: (2017)

Measuring microtubule binding kinetics of membrane-bound kinesin motors using supported lipid bilayers
por: Jiang, Rui, et al.
Publicado: (2021)

CHOYCE: a web server for constrained homology modelling with cryoEM maps
por: Rawi, Reda, et al.
Publicado: (2010)

Delineation of the TRAK binding regions of the kinesin-1 motor proteins
por: Randall, Thomas S., et al.
Publicado: (2013)

The mechanism of kinesin inhibition by kinesin-binding protein
por: Atherton, Joseph, et al.
Publicado: (2020)

Microtubule organization by the antagonistic mitotic motors kinesin-5 and kinesin-14
por: Hentrich, Christian, et al.
Publicado: (2010)

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding
por: Solon, April L., et al.
Publicado: (2021)

Publisher Correction: Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins
por: Wang, Xiangli, et al.
Publicado: (2021)

A new model for binding of kinesin 13 to curved microtubule protofilaments
por: Mulder, Anke M., et al.
Publicado: (2009)

Corrigendum to “Cryo-EM Structure (4.5 Å) of Yeast Kinesin-5–Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance” [J. Mol. Biol. 431 (2019) 864-872] https://doi.org/10.1016/j.jmb.2019.01.011
por: von Loeffelholz, Ottilie, et al.
Publicado: (2020)

Mechanical splitting of microtubules into protofilament bundles by surface-bound kinesin-1
por: VanDelinder, Virginia, et al.
Publicado: (2016)

Kinesin motor density and dynamics in gliding microtubule motility
por: VanDelinder, Virginia, et al.
Publicado: (2019)

Active Bending of Disordered Microtubule Bundles by Kinesin Motors
por: Nasirimarekani, Vahid, et al.
Publicado: (2022)

Cryo-EM structure of substrate-bound human telomerase holoenzyme
por: Nguyen, Thi Hoang Duong, et al.
Publicado: (2018)

Different motilities of microtubules driven by kinesin-1 and kinesin-14 motors patterned on nanopillars
por: Kaneko, Taikopaul, et al.
Publicado: (2020)

The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips
por: Chen, Xiuzhen, et al.
Publicado: (2023)

Visualising the cytoskeletal machinery in neuronal growth cones using cryo-electron tomography
por: Atherton, Joseph, et al.
Publicado: (2022)

Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule
por: Lacey, Samuel E, et al.
Publicado: (2019)

Structural differences between yeast and mammalian microtubules revealed by cryo-EM
por: Howes, Stuart C., et al.
Publicado: (2017)

A fast mathematical programming procedure for simultaneous fitting of assembly components into cryoEM density maps
por: Zhang, Shihua, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_brg50931am1dpeiich3shbnbqb