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Extending the Horizon of Homology Detection with Coevolution-based Structure Prediction
Traditional sequence analysis algorithms fail to identify distant homologies when they lie beyond a detection horizon. In this review, we discuss how co-evolution-based contact and distance prediction methods are pushing back this homology detection horizon, thereby yielding new functional insights...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527833/ https://www.ncbi.nlm.nih.gov/pubmed/34139218 http://dx.doi.org/10.1016/j.jmb.2021.167106 |