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Chemoselective cysteine or disulfide modification via single atom substitution in chloromethyl acryl reagents

The development of bioconjugation chemistry has enabled the combination of various synthetic functionalities to proteins, giving rise to new classes of protein conjugates with functions well beyond what Nature can provide. Despite the progress in bioconjugation chemistry, there are no reagents devel...

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Detalles Bibliográficos
Autores principales: Xu, Lujuan, Silva, Maria J. S. A., Gois, Pedro M. P., Kuan, Seah Ling, Weil, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528048/
https://www.ncbi.nlm.nih.gov/pubmed/34777751
http://dx.doi.org/10.1039/d1sc03250j