Expanding the scope of native chemical ligation – templated small molecule drug synthesis via benzanilide formation

We describe a reaction system that enables the synthesis of Bcr–Abl tyrosine kinase inhibitors (TKI) via benzanilide formation in water. The reaction is based on native chemical ligation (NCL). In contrast to previous applications, we used the NCL chemistry to establish aromatic rather than aliphati...

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Detalles Bibliográficos
Autores principales: Houska, Richard, Stutz, Marvin Björn, Seitz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528049/
https://www.ncbi.nlm.nih.gov/pubmed/34777764
http://dx.doi.org/10.1039/d1sc00513h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528049/
https://www.ncbi.nlm.nih.gov/pubmed/34777764
http://dx.doi.org/10.1039/d1sc00513h

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