Cargando…

Expanding the scope of native chemical ligation – templated small molecule drug synthesis via benzanilide formation

We describe a reaction system that enables the synthesis of Bcr–Abl tyrosine kinase inhibitors (TKI) via benzanilide formation in water. The reaction is based on native chemical ligation (NCL). In contrast to previous applications, we used the NCL chemistry to establish aromatic rather than aliphati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Houska, Richard, Stutz, Marvin Björn, Seitz, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528049/ https://www.ncbi.nlm.nih.gov/pubmed/34777764 http://dx.doi.org/10.1039/d1sc00513h

Ejemplares similares

Proximity Effects in Mass Spectra of Benzanilides
por: Fenwick, Nathan W, et al.
Publicado: (2021)

Template-directed ligation on repetitive DNA sequences: a chemical method to probe the length of Huntington DNA
por: Kern, Anika, et al.
Publicado: (2015)

Enabling Cysteine‐Free Native Chemical Ligation at Challenging Junctions with a Ligation Auxiliary Capable of Base Catalysis
por: Fuchs, Olaf, et al.
Publicado: (2021)

Enhancing Auxiliary‐Mediated Native Chemical Ligation at Challenging Junctions with Pyridine Scaffolds
por: Trunschke, Sebastian, et al.
Publicado: (2022)

Templated chemistry for bioorganic synthesis and chemical biology
por: Seitz, Oliver
Publicado: (2019)

Triarylmethanes and their Medium‐Ring Analogues by Unactivated Truce–Smiles Rearrangement of Benzanilides
por: Abrams, Roman, et al.
Publicado: (2021)

Novel Promising Estrogenic Receptor Modulators: Cytotoxic and Estrogenic Activity of Benzanilides and Dithiobenzanilides
por: Kucinska, Malgorzata, et al.
Publicado: (2016)

Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
por: Jin, Shuaijiang, et al.
Publicado: (2020)

Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation
por: Richardson, Jonathan P., et al.
Publicado: (2008)

Native Chemical Ligation: A Boon to Peptide Chemistry
por: Thapa, Parashar, et al.
Publicado: (2014)

Nucleic Acid Templated Reactions for Chemical Biology
por: Di Pisa, Margherita, et al.
Publicado: (2017)

A new method of N to C sequential ligation using thioacid capture ligation and native chemical ligation
por: Hou, Wen, et al.
Publicado: (2018)

A diversity-oriented synthesis of bioactive benzanilides via a regioselective C(sp(2))–H hydroxylation strategy
por: Sun, Yong-Hui, et al.
Publicado: (2016)

Selective Desulfurization Significantly Expands Sequence Variety of 3′-Peptidyl–tRNA Mimics Obtained by Native Chemical Ligation
por: Geiermann, Anna-Skrollan, et al.
Publicado: (2012)

Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation
por: Dastpeyman, Mohadeseh, et al.
Publicado: (2021)

Arylsulfonylamino-Benzanilides as Inhibitors of the Apical Sodium-Dependent Bile Salt Transporter (SLC10A2)
por: Liu, Hong-Tao, et al.
Publicado: (2013)

Author Correction: Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
por: Jin, Shuaijiang, et al.
Publicado: (2021)

Native Chemical Ligation for Cross-Linking of Flower-Like Micelles
por: Najafi, Marzieh, et al.
Publicado: (2018)

A versatile o-aminoanilide linker for native chemical ligation
por: Sánchez-Campillo, Iván, et al.
Publicado: (2022)

Serine promoted synthesis of peptide thioester-precursor on solid support for native chemical ligation
por: Elashal, Hader E., et al.
Publicado: (2017)

Enabling Peptide Ligation at Aromatic Junction Mimics via Native Chemical Ligation and Palladium-Mediated S-Arylation
por: Lin, Xiaoxi, et al.
Publicado: (2023)

Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides
por: Hering, Anke, et al.
Publicado: (2022)

Shifting Native Chemical Ligation into Reverse through N→S Acyl Transfer
por: Macmillan, Derek, et al.
Publicado: (2011)

Enzyme‐Primed Native Chemical Ligation Produces Autoinducing Cyclopeptides in Clostridia
por: Molloy, Evelyn M., et al.
Publicado: (2021)

Efficient Synthesis of Peptide and Protein Functionalized Pyrrole-Imidazole Polyamides Using Native Chemical Ligation
por: Janssen, Brian M. G., et al.
Publicado: (2015)

Charting the Chemical and Mechanistic Scope of Light-Triggered Protein Ligation
por: Earley, Daniel F., et al.
Publicado: (2022)

Coupling of sterically demanding peptides by β-thiolactone-mediated native chemical ligation
por: Chen, Huan, et al.
Publicado: (2018)

Native Chemical Ligation of Highly Hydrophobic Peptides in Ionic Liquid-Containing Media
por: Baumruck, Andreas C., et al.
Publicado: (2021)

Template-directed Chemical Ligation to Obtain 3′-3′ and 5′-5′ Phosphodiester DNA Linkages
por: Chen, Haodong, et al.
Publicado: (2014)

Side-Chain Cysteine-Functionalized Poly(2-oxazoline)s for Multiple Peptide Conjugation by Native Chemical Ligation
por: Schmitz, Michael, et al.
Publicado: (2015)

Rapid oligonucleotide-templated fluorogenic tetrazine ligations
por: Šečkutė, Jolita, et al.
Publicado: (2013)

Template Directed Reversible Photochemical Ligation of Oligodeoxynucleotides
por: Nakamura, Shigetaka, et al.
Publicado: (2011)

Expanding the scope of Chemical Engineering Journal Advances
por: Pan, Bingcai, et al.
Publicado: (2022)

Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides
por: Ollivier, Nathalie, et al.
Publicado: (2018)

Native chemical ligation approach to sensitively probe tissue acyl-CoA pools
por: James, Andrew M., et al.
Publicado: (2022)

Orthogonal Covalent Entrapment of Cargo into Biodegradable Polymeric Micelles via Native Chemical Ligation
por: Hebels, Erik R., et al.
Publicado: (2022)

Template‐Directed Copying of RNA by Non‐enzymatic Ligation
por: Zhou, Lijun, et al.
Publicado: (2020)

New Deoxyribozymes for the Native Ligation of RNA
por: Scheitl, Carolin P. M., et al.
Publicado: (2020)

Post-Assembly Functionalization of Supramolecular Nanostructures with Bioactive Peptides and Fluorescent Proteins by Native Chemical Ligation
por: Khan, Saahir, et al.
Publicado: (2014)

Förster Resonance Energy Transfer Assay for Investigating the Reactivity of Thioesters in Biochemistry and Native Chemical Ligation
por: Gless, Bengt H., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_606t8gcuasanbtt32s7phm2g6n