Modelling the active SARS-CoV-2 helicase complex as a basis for structure-based inhibitor design

The RNA helicase (non-structural protein 13, NSP13) of SARS-CoV-2 is essential for viral replication, and it is highly conserved among the coronaviridae family, thus a prominent drug target to treat COVID-19. We present here structural models and dynamics of the helicase in complex with its native s...

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Detalles Bibliográficos
Autores principales: Berta, Dénes, Badaoui, Magd, Martino, Sam Alexander, Buigues, Pedro J., Pisliakov, Andrei V., Elghobashi-Meinhardt, Nadia, Wells, Geoff, Harris, Sarah A., Frezza, Elisa, Rosta, Edina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528070/
https://www.ncbi.nlm.nih.gov/pubmed/34777769
http://dx.doi.org/10.1039/d1sc02775a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528070/
https://www.ncbi.nlm.nih.gov/pubmed/34777769
http://dx.doi.org/10.1039/d1sc02775a

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