The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis

Male germ cell (GC) production is a metabolically driven and apoptosis-prone process. Here, we show that the glucose-sensing transcription factor (TF) MAX-Like protein X (MLX) and its binding partner MondoA are both required for male fertility in the mouse, as well as survival of human tumor cells d...

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Detalles Bibliográficos
Autores principales: Carroll, Patrick A., Freie, Brian W., Cheng, Pei Feng, Kasinathan, Sivakanthan, Gu, Haiwei, Hedrich, Theresa, Dowdle, James A., Venkataramani, Vivek, Ramani, Vijay, Wu, Xiaoying, Raftery, Daniel, Shendure, Jay, Ayer, Donald E., Muller, Charles H., Eisenman, Robert N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528285/
https://www.ncbi.nlm.nih.gov/pubmed/34669700
http://dx.doi.org/10.1371/journal.pbio.3001085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528285/
https://www.ncbi.nlm.nih.gov/pubmed/34669700
http://dx.doi.org/10.1371/journal.pbio.3001085

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