Engineering gene overlaps to sustain genetic constructs in vivo

Evolution is often an obstacle to the engineering of stable biological systems due to the selection of mutations inactivating costly gene circuits. Gene overlaps induce important constraints on sequences and their evolution. We show that these constraints can be harnessed to increase the stability o...

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Detalles Bibliográficos
Autores principales: Decrulle, Antoine L., Frénoy, Antoine, Meiller-Legrand, Thomas A., Bernheim, Aude, Lotton, Chantal, Gutierrez, Arnaud, Lindner, Ariel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528312/
https://www.ncbi.nlm.nih.gov/pubmed/34624014
http://dx.doi.org/10.1371/journal.pcbi.1009475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528312/
https://www.ncbi.nlm.nih.gov/pubmed/34624014
http://dx.doi.org/10.1371/journal.pcbi.1009475

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