Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma

Neuroblastoma cell identity depends on a core regulatory circuit (CRC) of transcription factors that collaborate with MYCN to drive the oncogenic gene expression program. For neuroblastomas dependent on the adrenergic CRC, treatment with retinoids can inhibit cell growth and induce differentiation....

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Detalles Bibliográficos
Autores principales: Zimmerman, Mark W., Durbin, Adam D., He, Shuning, Oppel, Felix, Shi, Hui, Tao, Ting, Li, Zhaodong, Berezovskaya, Alla, Liu, Yu, Zhang, Jinghui, Young, Richard A., Abraham, Brian J., Look, A. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528416/
https://www.ncbi.nlm.nih.gov/pubmed/34669465
http://dx.doi.org/10.1126/sciadv.abe0834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528416/
https://www.ncbi.nlm.nih.gov/pubmed/34669465
http://dx.doi.org/10.1126/sciadv.abe0834

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