Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates

The microtubule-associated protein tau aggregates in multiple neurodegenerative diseases, causing inflammation and changing the inflammatory signature of microglia by unknown mechanisms. We have shown that microglia phagocytose live neurons containing tau aggregates cultured from P301S tau mice due...

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Detalles Bibliográficos
Autores principales: Brelstaff, Jack H., Mason, Matthew, Katsinelos, Taxiarchis, McEwan, William A., Ghetti, Bernardino, Tolkovsky, Aviva M., Spillantini, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528424/
https://www.ncbi.nlm.nih.gov/pubmed/34669475
http://dx.doi.org/10.1126/sciadv.abg4980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528424/
https://www.ncbi.nlm.nih.gov/pubmed/34669475
http://dx.doi.org/10.1126/sciadv.abg4980

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