Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle

Circadian rhythms are generated by an autoregulatory feedback loop of transcriptional activators and repressors. Circadian rhythm disruption contributes to type 2 diabetes (T2D) pathogenesis. We elucidated whether altered circadian rhythmicity of clock genes is associated with metabolic dysfunction...

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Detalles Bibliográficos
Autores principales: Gabriel, Brendan M., Altıntaş, Ali, Smith, Jonathon A. B., Sardon-Puig, Laura, Zhang, Xiping, Basse, Astrid L., Laker, Rhianna C., Gao, Hui, Liu, Zhengye, Dollet, Lucile, Treebak, Jonas T., Zorzano, Antonio, Huo, Zhiguang, Rydén, Mikael, Lanner, Johanna T., Esser, Karyn A., Barrès, Romain, Pillon, Nicolas J., Krook, Anna, Zierath, Juleen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528429/
https://www.ncbi.nlm.nih.gov/pubmed/34669477
http://dx.doi.org/10.1126/sciadv.abi9654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528429/
https://www.ncbi.nlm.nih.gov/pubmed/34669477
http://dx.doi.org/10.1126/sciadv.abi9654

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