An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium

Efficient IgA transcytosis is critical for the maintenance of a homeostatic microbiota. In the canonical model, locally-secreted dimeric (d)IgA reaches the polymeric immunoglobulin receptor (pIgR) on intestinal epithelium via simple diffusion. A role for integrin αE(CD103)β7 during transcytosis has...

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Detalles Bibliográficos
Autores principales: Guzman, Mauricio, Lundborg, Luke R., Yeasmin, Shaila, Tyler, Christopher J., Zgajnar, Nadia R., Taupin, Vanessa, Dobaczewska, Katarzyna, Mikulski, Zbigniew, Bamias, Giorgos, Rivera-Nieves, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528714/
https://www.ncbi.nlm.nih.gov/pubmed/34417548
http://dx.doi.org/10.1038/s41385-021-00439-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528714/
https://www.ncbi.nlm.nih.gov/pubmed/34417548
http://dx.doi.org/10.1038/s41385-021-00439-x

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