Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK

The SH2B family of adaptor proteins, SH2-B, APS, and LNK are key modulators of cellular signalling pathways. Whilst SH2-B and APS have been partially structurally and biochemically characterised, to date there has been no such characterisation of LNK. Here we present two crystal structures of the LN...

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Detalles Bibliográficos
Autores principales: Morris, Rhiannon, Zhang, Yaoyuan, Ellyard, Julia I., Vinuesa, Carola G., Murphy, James M., Laktyushin, Artem, Kershaw, Nadia J., Babon, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528861/
https://www.ncbi.nlm.nih.gov/pubmed/34671038
http://dx.doi.org/10.1038/s41467-021-26394-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528861/
https://www.ncbi.nlm.nih.gov/pubmed/34671038
http://dx.doi.org/10.1038/s41467-021-26394-6

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