Genetic landscape of T cells identifies synthetic lethality for T-ALL

To capture the global gene network regulating the differentiation of immature T cells in an unbiased manner, large-scale forward genetic screens in zebrafish were conducted and combined with genetic interaction analysis. After ENU mutagenesis, genetic lesions associated with failure of T cell develo...

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Detalles Bibliográficos
Autores principales: O’Meara, Connor P., Guerri, Lucia, Lawir, Divine-Fondzenyuy, Mateos, Fernando, Iconomou, Mary, Iwanami, Norimasa, Soza-Ried, Cristian, Sikora, Katarzyna, Siamishi, Iliana, Giorgetti, Orlando, Peter, Sarah, Schorpp, Michael, Boehm, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528931/
https://www.ncbi.nlm.nih.gov/pubmed/34671088
http://dx.doi.org/10.1038/s42003-021-02694-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528931/
https://www.ncbi.nlm.nih.gov/pubmed/34671088
http://dx.doi.org/10.1038/s42003-021-02694-x

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