Pharmacological Inhibition of Core Regulatory Circuitry Liquid–liquid Phase Separation Suppresses Metastasis and Chemoresistance in Osteosarcoma

Liquid–liquid phase‐separated (LLPS) transcriptional factor assemblies at super‐enhancers (SEs) provide a conceptual framework for underlying transcriptional control in mammal cells. However, the mechanistic understanding of LLPS in aberrant transcription driven by dysregulation of SEs in human mali...

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Detalles Bibliográficos
Autores principales: Lu, Bing, Zou, Changye, Yang, Meiling, He, Yangyang, He, Jincan, Zhang, Chuanxia, Chen, Siyun, Yu, Jiaming, Liu, Kilia Yun, Cao, Qi, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529446/
https://www.ncbi.nlm.nih.gov/pubmed/34432948
http://dx.doi.org/10.1002/advs.202101895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529446/
https://www.ncbi.nlm.nih.gov/pubmed/34432948
http://dx.doi.org/10.1002/advs.202101895

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