Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase involved in cellular innate immunity, metabolism, and senescence. FK506-binding protein 12 (FKBP12) inhibits mTOR kinase activity via direct association. The FKBP12-mTOR association can be strengthened by the immunosuppressant rap...

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Detalles Bibliográficos
Autores principales: Hu, Lin, Chen, Fuxian, Wu, Chao, Wang, Jun, Chen, Si-si, Li, Xiang-rong, Wang, Jing, Wu, Linpeng, Ding, Jian-ping, Wang, Jian-chuan, Huang, Chao, Zheng, Hui, Rao, Yu, Sun, Yu, Chang, Zhijie, Deng, Wei, Luo, Cheng, Chin, Y. Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529501/
https://www.ncbi.nlm.nih.gov/pubmed/34712915
http://dx.doi.org/10.1016/j.isci.2021.103177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529501/
https://www.ncbi.nlm.nih.gov/pubmed/34712915
http://dx.doi.org/10.1016/j.isci.2021.103177

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