Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide

Delivering peptides into cells could open up possibilities for targeting intracellular proteins. Although fatty acylation of peptide therapeutics improves their systemic half-life, it remains unclear how it influences their cellular uptake. Here, we demonstrate that a fatty acylated peptide exhibits...

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Detalles Bibliográficos
Autores principales: Gao, Xinxin, Mazière, Ann De, Beard, Rhiannon, Klumperman, Judith, Hannoush, Rami N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529511/
https://www.ncbi.nlm.nih.gov/pubmed/34712919
http://dx.doi.org/10.1016/j.isci.2021.103220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529511/
https://www.ncbi.nlm.nih.gov/pubmed/34712919
http://dx.doi.org/10.1016/j.isci.2021.103220

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